Synthesis of N-Substituted 3-Chloro- 2-azetidinones for 2, 4-diamino-6- hydroxy pyrimidin

This search involved synthesis of several new N-Substituted -3-chloro-
 2-azetidinones which were known as a high medicinal effectiveness for 2,
 4-Diamino-6-hydroxy pyrimidin in two steps. The first step included
 preparation Shiff bases (1-6) by condensation 2, 4-Diamino-6-hydroxy
 with many substituted aldehydes(4-hydroxy benzaldehyde, 2-
 bromobenzaldehyde, 4-dimethyl amino = 4-nitro
 salicylaldehyde, 4-chlorobenzaldehyde), then the second
 included, six azetidinones compounds (7-12) by
 reaction chloroacetylchloride prepared Schiff first
 presence triethylamine. structures synthesized
 were- characterized physical properties (FT-IR, UV and
 some them 'H-NMR, C_NMR spectroscopy) recorded.